Fragile X Proteins Involved in Proper Neuron Development

Recent findings may offer a new understanding of the condition fragile X syndrome, which is known as one of the most common genetic intellectual disabilities, and is strongly cited as the greatest contributor to autism spectrum disorder. The study, conducted by the University of Wisconsin-Madison Waisman Center, published in the journal Cell Reports, found that two critical proteins in fragile X appeared to impact cognitive development of neurons in mice. Their two proteins were revealed (FMRP and FXR2P) to have distinct mechanisms in neuron creation, drawing into question what causes the malfunction and how it can be prevented on a genetic level. “The findings suggest that fostering new nerve cell development during the postnatal period may have therapeutic potential for people with fragile X syndrome and other neurological disorders,” explained the lead researcher of the study. “If we can find a way to reactivate the FMRP gene, we may be able to treat the disease.” To learn more about this study, click here.