Researchers Decode How the Brain Miswires, Possibly Causing ADHD

Findings from a recent study published in the journal Neuron have shed light on why neurons in the brain’s reward system can be miswired, potentially contributing to disorders such as attention deficit hyperactivity disorder (ADHD). The results from the study may increase the understanding of underlying causes of ADHD, facilitating the development of more individualized treatments. During the study, researchers uncovered a receptor system that plays a critical role during embryonic development for correct wiring of the dopaminergic brain area. However, they also discovered that after brain maturation, a cut in the same receptor, SorCS2, produces a two-chain receptor that induces cell death following damage to the peripheral nervous system. In a mouse study, researchers found that the miswiring of dopaminergic neurons in mice results in hyperactivity and attention deficits. To read more about this study, click here.