Compound Reverses Symptoms of Alzheimer’s Disease in Mice

A new molecular compound restored learning, memory and appropriate behavior in a mouse model of Alzheimer’s disease. According to findings recently reported in the Journal of Alzheimer’s Disease, the molecule, developed by Saint Louis University scientists, also reduced inflammation in the part of the brain responsible for learning and memory. Scientists tested the compound, called antisense oligonucleotide (OL-1), in a type of mouse that overexpresses a mutant form of the human amyloid beta precursor gene. The mice were given a series of tests designed to measure memory, learning and appropriate behavior, such as going through a maze, exploring an unfamiliar location and recognizing an object. The scientists found that learning and memory improved in the genetically engineered mice that received OL-1, compared to the genetically engineered mice that received random antisense, a strand of molecules that bind to messenger RNA, launching a cascade of cellular events that turns off a certain gene. “Our findings reinforced the importance of amyloid beta protein in the Alzheimer’s disease process. They suggest that an antisense that targets the precursor to amyloid beta protein is a potential therapy to explore to reversing symptoms of Alzheimer’s disease,” said Susan Farr, PhD, who led the study. To learn more about the study, click here.