Toxin from Brain Cells Triggers Neuron Loss in Human ALS Model

Researchers from Columbia University reported in a recent study that toxins released by cells that normally nurture neurons in the brain and spinal cord can trigger loss of nerve cells that are affected by amyotrophic lateral sclerosis (ALS). The toxin is produced by star-shaped cells, called astrocytes, and kills nearby motor neurons. The death of motor neurons causes a loss of muscle control required for movement, breathing, and swallowing. Researchers have not yet identified the toxin released by the astrocytes, but were able to examine the neuronal death process triggered by the toxin. The findings may lead to a way to prevent motor neuron death in patients and potentially prolong their lives. To read more about this study, click here.