New Molecular Feedback Process May Protect Against Alzheimer’s Disease

New research conducted by Rockefeller University has identified a series of naturally occurring molecular steps — known as a pathway — that can dampen the production of amyloid-β, the key toxic protein fragments indicated in Alzheimer’s disease. “Our discovery centers on a protein called WAVE1, which we found to be important in the production of amyloid-β. The reduction of WAVE1 appears to have a protective effect against the disease,” said the study’s lead author. “When levels of amyloid-β rise, there is an accompanying increase in another molecule, AICD, which reduces the expression of WAVE1. This has the effect of reducing the production of amyloid-β. To take a closer look at the relationship between amyloid-β and WAVE1, the researchers tested the brains and memories of mice genetically altered to produce high levels of amyloid-β and varying levels of WAVE1. They found a dose-dependent response — mice brains with low WAVE1 levels produced less amyloid-β, and these animals performed better on memory tests. To read more about this study, click here.